About a week ago I got a new mouse for my daily work use. It is not your normal Apple “one button mouse” for sure. I got the new Evoluent VerticalMouse. As it sounds, your hand sits vertically around the mouse. I find it quite comfortable and after a couple of days I got quite used to it. It has 5 buttons including the one on the scroll wheel (however, they don’t provide free Mac drivers – you have to buy them from someone else if you want more than two buttons and the scroll wheel). If your hand hurts from mousing, give this a try.